November 18, 2022 Sebia, Inc. Karen Anderson Director of Regulatory 1705 Corporate Drive, Suite 400 Norcross, Georgia 30093 Re:
![Evolution of kappa, lambda light chain level and kappa/lambda ratio (A)... | Download Scientific Diagram Evolution of kappa, lambda light chain level and kappa/lambda ratio (A)... | Download Scientific Diagram](https://www.researchgate.net/publication/298484007/figure/fig2/AS:340336573468698@1458153970403/Evolution-of-kappa-lambda-light-chain-level-and-kappa-lambda-ratio-A-and-liver.png)
Evolution of kappa, lambda light chain level and kappa/lambda ratio (A)... | Download Scientific Diagram
![PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With](https://www.researchgate.net/publication/325548624/figure/tbl2/AS:669120525787137@1536542173032/Distribution-of-Patients-With-Neoplastic-Monoclonal-Gammopathies-With-SFLCA-Results_Q320.jpg)
PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With
![PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With](https://www.researchgate.net/publication/325548624/figure/tbl1/AS:669120521572363@1536542172993/Distribution-of-SFLCA-Results-of-Patients-With-Monoclonal-Gammopathies-Categorized-by_Q320.jpg)
PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With
![Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/682f4ccc-f7aa-4d0f-a62d-de5f2d44a6b4/cup13858-fig-0001-m.jpg)
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library
The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma
![PDF) Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance (MGUS) PDF) Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance (MGUS)](https://www.researchgate.net/profile/Dirk-Larson/publication/7883288/figure/tbl2/AS:601807722127390@1520493550610/Absolute-Risk-of-Progression-of-MGUS-to-Myeloma-or-Related-Disorders-Based-on-the-Serum_Q320.jpg)
PDF) Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance (MGUS)
![Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/pr5005967/asset/images/large/pr-2014-005967_0001.jpeg)
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma](https://www.researchgate.net/publication/343542653/figure/fig2/AS:934204644806656@1599743152174/Distribution-of-light-chain-ratios-of-A-kappa-dominance-and-B-lambda-dominance_Q320.jpg)
PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma
![Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses - ScienceDirect Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124721012250-fx1.jpg)
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses - ScienceDirect
Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels | Haematologica
![Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study | Blood Cancer Journal Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study | Blood Cancer Journal](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41408-022-00732-3/MediaObjects/41408_2022_732_Fig1_HTML.png)
Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study | Blood Cancer Journal
![Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0324-0/MediaObjects/13046_2016_324_Fig1_HTML.gif)
Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research
![State of the Art Symposium: Flow cytometry in the diagnosis of lymphoproliferative disorders by fine‐needle aspiration - Jorgensen - 2005 - Cancer Cytopathology - Wiley Online Library State of the Art Symposium: Flow cytometry in the diagnosis of lymphoproliferative disorders by fine‐needle aspiration - Jorgensen - 2005 - Cancer Cytopathology - Wiley Online Library](https://acsjournals.onlinelibrary.wiley.com/cms/asset/2aa19646-3f0b-4865-a83a-ed5470ea2032/mfig008.jpg)
State of the Art Symposium: Flow cytometry in the diagnosis of lymphoproliferative disorders by fine‐needle aspiration - Jorgensen - 2005 - Cancer Cytopathology - Wiley Online Library
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/062e85a70c6f2d44975de989760becdae280cc49/3-Figure2-1.png)
PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar
![Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis](https://www.frontiersin.org/files/Articles/974392/frhem-01-974392-HTML/image_m/frhem-01-974392-g001.jpg)
Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis
![Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/pr5005967/asset/images/large/pr-2014-005967_0003.jpeg)
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/ec451350-c748-4112-a036-ef938dcc377c/cup13858-fig-0002-m.jpg)
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library
![PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With](https://i1.rgstatic.net/publication/325548624_Serum_Free_Light_Chains_in_Neoplastic_Monoclonal_Gammopathies_Relative_Under-Detection_of_Lambda_Dominant_KappaLambda_Ratio_and_Underproduction_of_Free_Lambda_Light_Chains_as_Compared_to_Kappa_Light_C/links/5b15399b4585150a0a674cbd/largepreview.png)
PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With
![International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders | Leukemia International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders | Leukemia](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fleu.2008.307/MediaObjects/41375_2009_Article_BFleu2008307_Fig1_HTML.jpg)
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders | Leukemia
![Table 2 from Prevalence and clinical significance of abnormal serum kappa/lambda light chain ratio in patients with chronic kidney disease. | Semantic Scholar Table 2 from Prevalence and clinical significance of abnormal serum kappa/lambda light chain ratio in patients with chronic kidney disease. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/1444d9fcd1aa06934208ca29e69340f3ca084cbe/3-Table2-1.png)